Association of prenatal obesity and cord blood cytokine levels with allergic diseases in children: A 10-year follow-up cohort study

Background and aimAlthough studies have associated elevated prenatal obesity with increased risk of various diseases in offspring, little is known regarding the immune system. The aim this study was to evaluate relationship between levels cytokines umbilical cord blood development allergic disease during first 10 years life an offspring.MethodsA cohort term infants born at ShaoXing Women Children Hospitals China 2011 enrolled study. Flow cytometry performed measure cytokines, namely IL1β, IL2, IL10, IL6, IL8, IL17, IL12, TNF-α IFN-γ. Next, logistic regression used explore association BMI disease. each cytokine BMI, tested using linear analyses, respectively.ResultsAfter follow-up, higher significantly children (HR = 2.45, 95% CI:1.08–5.57, P 0.033). We also adjusted for maternal age, education infant gender, found that IL12 (P 0.023) IL1β 0.049) blood. Moreover, we education, dermatitis, gestation age increase unit (1.26 pg/ml) IL17 a 55.5% 10-year-old 1.55, 95%Cl: 0.99–2.45, 0.056). Meanwhile, after adjusting level, gestational weight gain, gender birthweight, every IL6 overweight/obesity 10-year follow-up by 18.7% 1.19, 1.01–1.40, 0.042), 13.9% 1.14, 1.02–1.27, 0.021) 41.3% 1.41, 1.02–1.95, 0.036), respectively.ConclusionsPrenatal positively correlated offspring. Cord may play mediating roles associations offspring diseases.